Intradermal immunization of mice with cholera toxin B-pneumococcal surface protein A fusion protein is protective against intraperitoneal challenge with Streptococcus pneumoniae.
نویسندگان
چکیده
Intradermal Immunization of Mice with Cholera Toxin B-Pneumococcal Surface Protein A Fusion Protein Is Protective against Intraperitoneal Challenge with Streptococcus pneumoniae Ana Paula Mattos Arêas, Maria Leonor Sarno Oliveira, Eliane Namie Miyaji, Luciana Cezar Cerqueira Leite, and Paulo Lee Ho* Centro de Biotecnologia, Instituto Butantan, São Paulo, Brazil; Instituto de Quı́mica, USP, São Paulo, Brazil; and Instituto de Biociências, USP, São Paulo, Brazil
منابع مشابه
Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice.
One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we de...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 73 6 شماره
صفحات -
تاریخ انتشار 2005